LL-37 5mg

• Form: Lyophilized powder
• Purity: >99%

Overview

LL-37 5mg, also known as Cathelicidin, is a cationic peptide composed of 37 amino acids. It is primarily found in neutrophils and produced by the extracellular breakdown of hCAP18 proteins through protease activity. LL-37 has been researched extensively for its antimicrobial properties and role in immune defense.

Research Background

Antimicrobial peptides like LL-37 are structured to target bacteria, fungi, and some viral strains. Unlike traditional antibiotics, they often act in a non-specific manner, which researchers believe makes it difficult for pathogens to develop resistance. LL-37 is classified as an α-helical peptide and is considered critical for maintaining innate immunity against microbes.

Mechanism of Interest

• Membrane interaction: Suggested to bind to bacterial membranes via electrostatic properties, followed by lateral diffusion across the lipid layer.
• Membrane disruption: Studies suggest mechanisms including pore formation or direct destabilization of microbial membranes, leading to cell death.
• Protective stability: May form agglomerates and lipid bilayers, potentially shielding it from rapid enzymatic degradation.

Molecular Information

• Molecular Formula: C205H340N50O53
• Molecular Weight: 4493.34 g/mol
• Other Names: CAP-18

Related Resources

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  ➡️ https://bionexpeptides.com/product-category/research-peptides/
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• Learn peptide fundamentals:
  ➡️ https://en.wikipedia.org/wiki/Peptide