🔬 ARA-290 10mg Overview
Form: Lyophilized powder
Purity: >99%
ARA-290, also known as cibinetide and helix B surface peptide (HBSP), is an 11–amino acid chain derived from the beta domain of erythropoietin (EPO). Unlike full EPO, which primarily stimulates red blood cell production, ARA-290 10mg was developed to investigate tissue regeneration, repair, and anti-inflammatory activity without hematopoietic effects.
🧪 Research Background
ARA-290 10mg is thought to act on the tissue-protective receptor (TPR), also called the innate repair receptor (IRR), a complex of CD131 and part of the EPO receptor. By binding to this receptor, ARA-290 10mg may initiate regenerative and anti-nociceptive pathways without promoting erythropoiesis.
Researchers suggest it may modulate pain signaling, inflammation, and cellular repair processes.
⚗️ Mechanism of Interest
🧠 Nociception
Studies indicate ARA-290 10mg may attenuate nerve pain (allodynia) by modulating TRPV1 channels, reducing sensitivity to capsaicin-induced activation in murine models.
🔥 Anti-inflammatory Effects
Experimental findings suggest ARA-290 10mg may lower pro-inflammatory cytokines (IL-1β, TNF-α) and influence microglial activity in models of retinal ischemia.
🩸 Vascular Protection
Research indicates potential protection of endothelial cells and enhanced vascular repair capacity when paired with endothelial colony-forming cells (ECFCs) in ischemic retinopathy models.
📊 Scientific Studies
Preclinical research has explored ARA-290 10mg in multiple areas:
- Murine neural studies: Demonstrated potential to reduce capsaicin-induced nociceptive signaling via TRPV1 inhibition
- Pain modulation: In vivo studies reported reduced sensitivity and fewer nociceptive responses after capsaicin challenge
- Retinal ischemia: Suggested possible benefits for vascular repair and inflammation control
🧬 Molecular Information
- Molecular Formula: C51H54N16O21
- Molecular Weight: 1257.3 g/mol
- Other Names: Cibinetide, HBSP, PH-BSP
🔗 Related Resources
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