PNC-27 10mg

Advanced Cellular Signaling and Selective Membranolysis Studies.

When you shop PNC-27 10mg from Bionex Peptides, you are obtaining a sophisticated research tool derived from the third helix of the p53 tumor suppressor protein. PNC-27 is a membrane-active peptide that has gained significant attention in medical studies for its potential to mitigate the proliferation of malignant cells through a unique, non-apoptotic pathway.

## Mechanism of Action: Selective Necrosis

Unlike many research chemicals that induce apoptosis, PNC-27 is studied for its ability to induce necrosis. Research suggests that:

• HDM2 Targeting: The peptide specifically binds to the HDM2 (Human Double Minute 2) protein, which is reported to be over-expressed on the membranes of carcinogenic cells.

• Pore Formation: This binding interaction appears to form a 1:1 complex that perforates the cancer cell membrane, creating transmembrane pores.

• Membranolysis: These “holes” lead to an influx of ions and the efflux of cellular contents, resulting in direct physical disruption and cell death while leaving non-cancerous cells intact.

## Product Specifications

• Peptide Name: PNC-27

• Concentration: 5mg per vial

• Purity: 99%+ HPLC & MS Verified

• Source: Derived from p53 (ASPP2) residues

• Format: Lyophilized Professional Grade Powder

• Storage: Store at -20°C for maximum stability and bio-activity.

## Key Research Insights

1. Selective Toxicity: Studies from 2009 indicate that PNC-27 shows affinity only toward cells expressing HDM2 on their surface, highlighting its potential for selective toxicity.

2. Structural Integrity: Research using dual-label fluorescence in 2010 suggests that PNC-27 acts as an intact peptide rather than fragments to effectively induce membranolytic activity.

3. Broad Spectrum Potential: Investigated across various cell lines including pancreatic cancer, ovarian cancer, leukemia, and breast tumor models (MCF-7).

## Why Source from Bionex Peptides?

• America’s Premier Source: We provide the highest-grade research materials to ensure your laboratory protocols are supported by absolute consistency.

• HPLC Verified Quality: Every vial of PNC-27 10mg undergoes rigorous batch testing to guarantee a 99%+ purity profile.

• Rapid & Discreet Logistics: Fast, secure, and temperature-controlled shipping across the United States to protect your research timelines.

Related Resources

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