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Ipamorelin is a synthetic peptide composed of five amino acids, classified as a Growth Hormone Secretagogue (GHS). Its structure is Aib-His-D-2-Nal-D-Phe-Lys-NH2. Ipamorelin was designed to bind to ghrelin receptors (GHS-R) on the pituitary gland, which regulate natural growth hormone (hGH) secretion. This peptide is recognized for being one of the first highly selective synthetic GHS compounds.
Ipamorelin is studied for its potential to selectively stimulate growth hormone release without significantly affecting other pituitary hormones such as prolactin or ACTH. By promoting hGH secretion, Ipamorelin may indirectly increase IGF-1 production, which mediates many of hGH’s anabolic actions, including tissue growth, cellular repair, and bone and muscle metabolism.