📑 PNC-27 5mg – Research Peptide for Cancer Studies

🔬 Product Overview

PNC-27 5mg is a 27-amino acid peptide studied for its potential to mitigate the activity and proliferation of cancer cells. It is derived from the third helix of the anti-cancer peptide α-helical segment of p53 (ASPP2), a protein involved in tumor suppression.

This peptide has been suggested to induce cell death via necrosis in various cancer cell lines, including pancreatic cancer, ovarian cancer, and leukemia. Importantly, PNC-27 selectively targets cancer cells without affecting normal cells.

🧪 Research Background

• Initially synthesized in 2000 as part of HIV-related immunodeficiency research
• Binds with HDM-2 protein, overly expressed on cancer cell membranes
• Induces necrosis rather than apoptosis, disrupting cancer cell plasma membranes via membranolysis
• Forms 1:1 complexes with HDM-2, leading to transmembrane pore formation
• Confirmed through immuno-electron microscopy to selectively perforate cancer cells while sparing normal cells

⚙️ Mechanism of Interest

• Cancer Cell Selectivity: Targets cells expressing HDM-2 protein
• Membranolytic Activity: Forms pores in the plasma membrane, allowing ion influx and cellular efflux
• Necrosis Induction: Leads to cancer cell death without apoptosis
• Structural Integrity: Remains intact during membrane interaction, crucial for cytotoxic activity

🔬 Key Research Observations

• Studies show punctate yellow fluorescence in cancer cell membranes, confirming peptide integrity
• LDH release correlates with increased cell death
• Non-cancerous cells remain unaffected unless HDM-2 is artificially expressed
• Research from 2009–2014 confirms selective pore formation and necrosis induction

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